The underlying research interest in Goswami Lab lies in understanding the role of molecules/components which have been long known to be critical for human health but have been 'taken for granted' without deep mechanistic insights. Elucidating the function of such components in immune system including but not limited to micronutrients like fat-soluble vitamins provide the key questions. Our quest in underlining the impact of such molecules/components in maintaining the homeostasis led us to ask the following questions:
a) How do fat-soluble vitamins regulate the differentiation of CD4+ T cells? b) How do these vitamins differentially regulate the expression of cytokines characteristic of distinct CD4+ T cell subsets? c) Is there any specific program/s that these vitamin/s use to regulate the expression of such cytokine/s irrespective of the CD4+ T cell subsets ? d) Can these vitamins be potentially be used as adjuvant therapy in various inflammatory (not limited to autoimmune) disorders? |
From the early characterized Th1 and Th2 cells, there has been addition of new members to the Th family. About a decade back, Interleukin (IL)-9-secreting Th9 cells were identified. Th9 cells play important role in the development of asthma, exacerbate ulcerative colitis; while they aid in the expulsion of helminthic infection and anti-tumor activity in mouse model of melanoma. We are currently defining how vitamin A and D regulate the development of Th2 and Th9 cells. Delineating the role of vitamin A and vitamin D in regulating the differentiation of Th9 cells will aid us developing future therapeutics.
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Apart from nutrients, hormones have been implicated in regulating Th cells development. Sex steroids may act directly on the immune system, altering antigen presentation, lymphocyte activation, and cytokine expression. The identification of estrogen and androgen receptors on immune cells provided a means for direct communication. Sex steroids also have indirect effects that must be considered. Some of the vitamins such as vitamin D has hormone like functions. Different sex hormones have been linked with autoimmunity with specific disease bias in women. Therefore we would also investigate how these sex steroid hormones control Th cell differentiation.
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Objectives
1. Effect of micronutrients (fat-soluble vitamins) on Th cell development and Macrophage polarization.
2. Transcriptional regulation of Th cell development with specific emphasis on Hox family transcription factors.
2. Role of sex steroid hormones in Th cell development.
2. Transcriptional regulation of Th cell development with specific emphasis on Hox family transcription factors.
2. Role of sex steroid hormones in Th cell development.
Selected Recent Publications in last 3 years
1. Biswas, B., Roy, S., Banerjee, I., Jana, S., Bhattacharjee, B., Chakraborty, S., Mondal, A., and Goswami, R. Interleukin-10 to Interleukin-6 Ratio in Swab Samples act as Decisive Hyper-Inflammatory Indicators for all Patients potentially infected with the SARS-CoV-2 Delta Variant. 2023. Heliyon. 9(6):e16985.
2. Biswas, B., Chattopadhyay, S., Hazra, S., Hansda, AK., and Goswami, R. COVID-19 pandemic: The Delta variant, T-cell responses and the efficacy of developing vaccines. 2022. Inflamm. Res. 71(4):377-396.
3. Banerjee, S., Biswas, SK., Kedia, N., Sarkar, R., Mitra, S., Roy, S., Chowdhury, R., Samaddar, S., Bandopadhyay, A., Banerjee, I., Jana, S., Goswami, R., Dutta, S., Chawla-Sarkar, M., Chakraborty, S., and Mondal, A. Piecewise Isothermal Nucleic Acid Testing (PINAT) for Infectious Disease Detection with Sample-to-Result Integration at the Point-of-Care. 2021. ACS Sens. 6(10):3753-3764.
4. Hansda, AK., and Goswami, R. 17-β Estradiol signalling affects cardiovascular and cancer pathogenesis by regulating the crosstalk between transcription factors and EC-miRNAs. 2021. Gene Reports. 24: 101295.
5. Vyas, SP., and Goswami. R. Calcitriol and Retinoic acid antagonize each other to suppress the production of IL-9 by Th9 cells. 2021. J. Nutr. Biochem. 96:108788.
6. Biswas, B., and Goswami, R. Differential Gene Expression Analysis in 1,25(OH)2D3 treated Human Monocytes establishes link between AIDS Progression, Neurodegenerative disorders, and Aging. 2021. Meta Gene. 28:100886.
7. Vyas SP, Srivastava RN, Goswami, R. Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of rheumatoid arthritis. Mol Cell Biochem. 2021. 476(1):369-384.
8. Vyas SP, Hansda AK, Kaplan MH, Goswami R. Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1. J Immunol. 2020;204(5):1201-1213.
2. Biswas, B., Chattopadhyay, S., Hazra, S., Hansda, AK., and Goswami, R. COVID-19 pandemic: The Delta variant, T-cell responses and the efficacy of developing vaccines. 2022. Inflamm. Res. 71(4):377-396.
3. Banerjee, S., Biswas, SK., Kedia, N., Sarkar, R., Mitra, S., Roy, S., Chowdhury, R., Samaddar, S., Bandopadhyay, A., Banerjee, I., Jana, S., Goswami, R., Dutta, S., Chawla-Sarkar, M., Chakraborty, S., and Mondal, A. Piecewise Isothermal Nucleic Acid Testing (PINAT) for Infectious Disease Detection with Sample-to-Result Integration at the Point-of-Care. 2021. ACS Sens. 6(10):3753-3764.
4. Hansda, AK., and Goswami, R. 17-β Estradiol signalling affects cardiovascular and cancer pathogenesis by regulating the crosstalk between transcription factors and EC-miRNAs. 2021. Gene Reports. 24: 101295.
5. Vyas, SP., and Goswami. R. Calcitriol and Retinoic acid antagonize each other to suppress the production of IL-9 by Th9 cells. 2021. J. Nutr. Biochem. 96:108788.
6. Biswas, B., and Goswami, R. Differential Gene Expression Analysis in 1,25(OH)2D3 treated Human Monocytes establishes link between AIDS Progression, Neurodegenerative disorders, and Aging. 2021. Meta Gene. 28:100886.
7. Vyas SP, Srivastava RN, Goswami, R. Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of rheumatoid arthritis. Mol Cell Biochem. 2021. 476(1):369-384.
8. Vyas SP, Hansda AK, Kaplan MH, Goswami R. Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1. J Immunol. 2020;204(5):1201-1213.
Book Chapters
1. Boosani, CS., and Goswami, R. Epigenetics regulations in organ specific disorders. 2022. Epigenetics in Organ-specific Disorders. 1-6.
2. Biswas, B., and Goswami, R. Epigenetics of T-cell mediated immune responses. 2022. Epigenetics in Organ-specific Disorders. 149-180.
3. Goswami, R. The structure-function bonhomie of JAK-STAT molecules. 2020. Jak-STAT Signaling in Diseases. 9-34.
4. Goswami, R., and Roy, DN. Toxicity of Terpenoids in Human Health. 2019. Terpenoids Against Human Diseases. 233-245.
5. Roy, DN., and Goswami, R. IL-9 Signaling Pathway: An Update. 2017. Methods. Mol. Biol. 1585:37-50.
6. Goswami, R. Th9 Cells: New Member of T Helper Cell Family. 2017. Methods. Mol. Biol. 1585:1-19.
2. Biswas, B., and Goswami, R. Epigenetics of T-cell mediated immune responses. 2022. Epigenetics in Organ-specific Disorders. 149-180.
3. Goswami, R. The structure-function bonhomie of JAK-STAT molecules. 2020. Jak-STAT Signaling in Diseases. 9-34.
4. Goswami, R., and Roy, DN. Toxicity of Terpenoids in Human Health. 2019. Terpenoids Against Human Diseases. 233-245.
5. Roy, DN., and Goswami, R. IL-9 Signaling Pathway: An Update. 2017. Methods. Mol. Biol. 1585:37-50.
6. Goswami, R. Th9 Cells: New Member of T Helper Cell Family. 2017. Methods. Mol. Biol. 1585:1-19.
Thematic Publications
1. Goswami, R., Blazquez, AB., Kosoy, R., Rahman, A., Nowak-Wegrzyn, A and Berin, MC. Systemic innate immune activation in food protein induced enterocolitis syndrome (FPIES). 2017. J. Allergy Clin. Immunol. pii: S0091-6749(17)30219-1.
2. Goswami, R., and Kaplan, MH. STAT transcription factors in T cell control of health and disease. 2017. Int. Rev. Cell Mol. Biol. 2017;331:123-180.
3. Goswami, R., and Kaplan, MH. Essential vitamins for an effective T cell response. 2016. World J. Immunol. 6(1): 39-59.
4. Tordesillas, L*., Goswami, R*., Benedé, S., Grishina, G., Dunkin, D., Järvinen, KM., Maleki, SJ., Sampson, HA., and Berin, MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. 2014. J. Clin. Invest. 124(11):4965-75. * Contributed equally.
5. Jabeen, R., Goswami, R., Awe, O., Kulkarni, A., Nguyen, ET., Attenasio, A., Walsh, D., Olson, MR., Kim, MH., Tepper, RS., Sun, J., Kim, C., Taparowsky, EJ., Zhou, B., and Kaplan, MH. Th9 cell development requires a BATF-regulated transcriptional network. 2013. J Clin Invest. 123(11):4641-53.
6. Goswami, R*., Jabeen, R*., Yagi, R., Pham, D., Zhu, J., Goenka, S., and Kaplan, MH. STAT6-dependent regulation of Th9 development. 2012. J. Immunol. 188(3): 968-975.*Contributed equally.
7. Goswami, R., and Kaplan, MH. Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. 2012. J. Immunol. 189(6): 3026-3033.
8. Chang, HC*., Sehra, S*., Goswami, R., Yao, W., Yu, Q., Stritesky, GL., Jabeen, R., Han, L., Nguyen, ET., McKinley, CD., Tepper, RS., Robertson, MJ., Perumal, NB., Nutt, SL., and Kaplan, MH. The transcription factor PU.1 is required for the development of IL-9-secreting T cells and allergic inflammation. 2010. Nat. Immunol. 11(6):527-534. * Contributed equally.
2. Goswami, R., and Kaplan, MH. STAT transcription factors in T cell control of health and disease. 2017. Int. Rev. Cell Mol. Biol. 2017;331:123-180.
3. Goswami, R., and Kaplan, MH. Essential vitamins for an effective T cell response. 2016. World J. Immunol. 6(1): 39-59.
4. Tordesillas, L*., Goswami, R*., Benedé, S., Grishina, G., Dunkin, D., Järvinen, KM., Maleki, SJ., Sampson, HA., and Berin, MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. 2014. J. Clin. Invest. 124(11):4965-75. * Contributed equally.
5. Jabeen, R., Goswami, R., Awe, O., Kulkarni, A., Nguyen, ET., Attenasio, A., Walsh, D., Olson, MR., Kim, MH., Tepper, RS., Sun, J., Kim, C., Taparowsky, EJ., Zhou, B., and Kaplan, MH. Th9 cell development requires a BATF-regulated transcriptional network. 2013. J Clin Invest. 123(11):4641-53.
6. Goswami, R*., Jabeen, R*., Yagi, R., Pham, D., Zhu, J., Goenka, S., and Kaplan, MH. STAT6-dependent regulation of Th9 development. 2012. J. Immunol. 188(3): 968-975.*Contributed equally.
7. Goswami, R., and Kaplan, MH. Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. 2012. J. Immunol. 189(6): 3026-3033.
8. Chang, HC*., Sehra, S*., Goswami, R., Yao, W., Yu, Q., Stritesky, GL., Jabeen, R., Han, L., Nguyen, ET., McKinley, CD., Tepper, RS., Robertson, MJ., Perumal, NB., Nutt, SL., and Kaplan, MH. The transcription factor PU.1 is required for the development of IL-9-secreting T cells and allergic inflammation. 2010. Nat. Immunol. 11(6):527-534. * Contributed equally.
Contact
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phone |
+91 3222 284570
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address |
School of Bio Science
Room 236 (Office)/ Room 120 (Lab) Life Science Building (Diamond Jubilee Complex) IIT Kharagpur |