FACULTY / RITOBRATA GOSWAMI
Immunology Lab |
|
2nd Floor
Sir JC Bose Laboratory Complex
IIT Kharagpur
Sir JC Bose Laboratory Complex
IIT Kharagpur
|
The current research interest lies in understanding the role of specific micro nutrients like vitamin in immune system. We are interested in understanding how the nutrients affect the adaptive immune system by regulating the development of T helper cells. T helper cells play important role in protecting us from various pathogens by producing cytokines. However, if unregulated the immune responses generated by T helper cells can cause various inflammatory disorders. Among different vitamins, role of vitamin A and vitamin D have been explored in the differentiation of specific T helper cells. In addition, the function of these vitamins have also been explored in disease models like allergic asthma and EAE. What is not known completely is how these molecules regulate the development of various Th cells.
|
|
From the early characterized Th1 and Th2 cells, there has been addition of new members to the Th family. About a decade back, Interleukin (IL)-9-secreting Th9 cells were identified. Th9 cells play important role in the development of asthma, exacerbate ulcerative colitis; while they aid in the expulsion of helminthic infection and anti-tumor activity in mouse model of melanoma. We are currently defining how vitamin A and D regulate the development of Th9 cells. Delineating the role of vitamin A and vitamin D in regulating the differentiation of Th9 cells will aid us developing future therapeutics.
|
|
|
Apart from nutrients, hormones have been implicated in regulating Th cells development. Sex steroids may act directly on the immune system, altering antigen presentation, lymphocyte activation, and cytokine expression. The identification of estrogen and androgen receptors on immune cells provided a means for direct communication. Sex steroids also have indirect effects that must be considered. Some of the vitamins such as vitamin D has hormone like functions. Different sex hormones have been linked with autoimmunity with specific disease bias in women. Therefore we would also investigate how these sex steroid hormones control Th cell differentiation.
|
Objectives
1. Effect of micro nutrients on Th cell development.
2. Transcriptional regulation of Th cell development.
2. Role of sex steroid hormones in Th cell development.
2. Transcriptional regulation of Th cell development.
2. Role of sex steroid hormones in Th cell development.
Recent publications
1. Vyas, SP., and Goswami. R. Calcitriol and Retinoic acid antagonize each other to suppressthe production of IL-9 by Th9 cells. J. Nutr. Biochem. Accepted.
2. Pal, A.,Goswami, R., and Roy DN. A critical assessment on biochemical and molecular mechanisms of toxicity developed by emerging nanomaterials on important microbes. Env. Nanotech.Monit. Man. Accepted.
3. Biswas, B., and Goswami, R. Differential Gene Expression Analysis in 1,25(OH)2D3 treated Human Monocytes establishes link between AIDS Progression, Neurodegenerative disorders, and Aging. 2021. Meta Gene. 28:100886.
4. Vyas SP, Srivastava RN, Goswami, R. Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of rheumatoid arthritis. Mol Cell Biochem. 2021. 476(1):369-384.
5. Majumdar M, Dubey A, Goswami R, Misra TK, Roy DN. In vitro and in silico studies on the structural and biochemical insight of anti-biofilm activity of andrograpanin from Andrographis paniculata against Pseudomonas aeruginosa. World J Microbial Biotechnol. 2020. 36(10):143
6. Goswami R, Awasthi A. Editorial: T Cell Differentiation and Function in Tissue Inflammation. Front Immunol. 2020 Feb 21;11:289
7. Vyas SP, Hansda AK, Kaplan MH, Goswami R. Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1. J Immunol. 2020;204(5):1201-1213.
8. Vyas SP, Hansda AK, Goswami R. Rheumatoid arthritis: 'melting pot' of T helper susbets. Int Rev Immunol. 2019;38(5):212-231
9. Vyas SP, Goswami R. Size-dependent cellular uptake and TLR4 attenuation by gold nanoparticles in lung adenocarcinoma cells. Nanomedicine (Lond). 2019;14(3):229-253.
10. Vyas SP, Goswami R. A Decade of Th9 Cells: Role of Th9 Cells in Inflammatory Bowel Disease. Front Immunol. 2018;9:1139.
11. Vyas SP, Goswami R. Striking the right immunological balance prevents the progression of tuberculosis. Inflamm Res. 2017;66(12):1031-1056.
2. Pal, A.,Goswami, R., and Roy DN. A critical assessment on biochemical and molecular mechanisms of toxicity developed by emerging nanomaterials on important microbes. Env. Nanotech.Monit. Man. Accepted.
3. Biswas, B., and Goswami, R. Differential Gene Expression Analysis in 1,25(OH)2D3 treated Human Monocytes establishes link between AIDS Progression, Neurodegenerative disorders, and Aging. 2021. Meta Gene. 28:100886.
4. Vyas SP, Srivastava RN, Goswami, R. Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of rheumatoid arthritis. Mol Cell Biochem. 2021. 476(1):369-384.
5. Majumdar M, Dubey A, Goswami R, Misra TK, Roy DN. In vitro and in silico studies on the structural and biochemical insight of anti-biofilm activity of andrograpanin from Andrographis paniculata against Pseudomonas aeruginosa. World J Microbial Biotechnol. 2020. 36(10):143
6. Goswami R, Awasthi A. Editorial: T Cell Differentiation and Function in Tissue Inflammation. Front Immunol. 2020 Feb 21;11:289
7. Vyas SP, Hansda AK, Kaplan MH, Goswami R. Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1. J Immunol. 2020;204(5):1201-1213.
8. Vyas SP, Hansda AK, Goswami R. Rheumatoid arthritis: 'melting pot' of T helper susbets. Int Rev Immunol. 2019;38(5):212-231
9. Vyas SP, Goswami R. Size-dependent cellular uptake and TLR4 attenuation by gold nanoparticles in lung adenocarcinoma cells. Nanomedicine (Lond). 2019;14(3):229-253.
10. Vyas SP, Goswami R. A Decade of Th9 Cells: Role of Th9 Cells in Inflammatory Bowel Disease. Front Immunol. 2018;9:1139.
11. Vyas SP, Goswami R. Striking the right immunological balance prevents the progression of tuberculosis. Inflamm Res. 2017;66(12):1031-1056.
Book Chapters
1. Biswas, B., and Goswami, R. Epigenetics of T-cell mediated immune responses. Epigenetics in Organ Specific Disorders. Under review.
2. Goswami, R. The structure-function bonhomie of JAK-STAT molecules. 2020. Jak-STAT Signaling in Diseases. 9-34.
3. Goswami, R., and Roy, DN. Toxicity of Terpenoids in Human Health. 2019. Terpenoids Against Human Diseases. 233-245.
4. Roy, DN., and Goswami, R. IL-9 Signaling Pathway: An Update. 2017. Methods. Mol. Biol. 1585:37-50.
5. Goswami, R. Th9 Cells: New Member of T Helper Cell Family. 2017. Methods. Mol. Biol. 1585:1-19.
2. Goswami, R. The structure-function bonhomie of JAK-STAT molecules. 2020. Jak-STAT Signaling in Diseases. 9-34.
3. Goswami, R., and Roy, DN. Toxicity of Terpenoids in Human Health. 2019. Terpenoids Against Human Diseases. 233-245.
4. Roy, DN., and Goswami, R. IL-9 Signaling Pathway: An Update. 2017. Methods. Mol. Biol. 1585:37-50.
5. Goswami, R. Th9 Cells: New Member of T Helper Cell Family. 2017. Methods. Mol. Biol. 1585:1-19.
Selected Publications
1. Goswami, R., Blazquez, AB., Kosoy, R., Rahman, A., Nowak-Wegrzyn, A and Berin, MC. Systemic innate immune activation in food protein induced enterocolitis syndrome (FPIES). 2017. J. Allergy Clin. Immunol. pii: S0091-6749(17)30219-1.
2. Goswami, R., and Kaplan, MH. STAT transcription factors in T cell control of health and disease. 2017. Int. Rev. Cell Mol. Biol. 2017;331:123-180.
3. Goswami, R., and Kaplan, MH. Essential vitamins for an effective T cell response. 2016. World J. Immunol. 6(1): 39-59.
4. Tordesillas, L*., Goswami, R*., Benedé, S., Grishina, G., Dunkin, D., Järvinen, KM., Maleki, SJ., Sampson, HA., and Berin, MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. 2014. J. Clin. Invest. 124(11):4965-75. * Contributed equally.
5. Jabeen, R., Goswami, R., Awe, O., Kulkarni, A., Nguyen, ET., Attenasio, A., Walsh, D., Olson, MR., Kim, MH., Tepper, RS., Sun, J., Kim, C., Taparowsky, EJ., Zhou, B., and Kaplan, MH. Th9 cell development requires a BATF-regulated transcriptional network. 2013. J Clin Invest. 123(11):4641-53.
6. Goswami, R*., Jabeen, R*., Yagi, R., Pham, D., Zhu, J., Goenka, S., and Kaplan, MH. STAT6-dependent regulation of Th9 development. 2012. J. Immunol. 188(3): 968-975.*Contributed equally.
7. Goswami, R., and Kaplan, MH. Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. 2012. J. Immunol. 189(6): 3026-3033.
8. Chang, HC*., Sehra, S*., Goswami, R., Yao, W., Yu, Q., Stritesky, GL., Jabeen, R., Han, L., Nguyen, ET., McKinley, CD., Tepper, RS., Robertson, MJ., Perumal, NB., Nutt, SL., and Kaplan, MH. The transcription factor PU.1 is required for the development of IL-9-secreting T cells and allergic inflammation. 2010. Nat. Immunol. 11(6):527-534. * Contributed equally.
2. Goswami, R., and Kaplan, MH. STAT transcription factors in T cell control of health and disease. 2017. Int. Rev. Cell Mol. Biol. 2017;331:123-180.
3. Goswami, R., and Kaplan, MH. Essential vitamins for an effective T cell response. 2016. World J. Immunol. 6(1): 39-59.
4. Tordesillas, L*., Goswami, R*., Benedé, S., Grishina, G., Dunkin, D., Järvinen, KM., Maleki, SJ., Sampson, HA., and Berin, MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. 2014. J. Clin. Invest. 124(11):4965-75. * Contributed equally.
5. Jabeen, R., Goswami, R., Awe, O., Kulkarni, A., Nguyen, ET., Attenasio, A., Walsh, D., Olson, MR., Kim, MH., Tepper, RS., Sun, J., Kim, C., Taparowsky, EJ., Zhou, B., and Kaplan, MH. Th9 cell development requires a BATF-regulated transcriptional network. 2013. J Clin Invest. 123(11):4641-53.
6. Goswami, R*., Jabeen, R*., Yagi, R., Pham, D., Zhu, J., Goenka, S., and Kaplan, MH. STAT6-dependent regulation of Th9 development. 2012. J. Immunol. 188(3): 968-975.*Contributed equally.
7. Goswami, R., and Kaplan, MH. Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. 2012. J. Immunol. 189(6): 3026-3033.
8. Chang, HC*., Sehra, S*., Goswami, R., Yao, W., Yu, Q., Stritesky, GL., Jabeen, R., Han, L., Nguyen, ET., McKinley, CD., Tepper, RS., Robertson, MJ., Perumal, NB., Nutt, SL., and Kaplan, MH. The transcription factor PU.1 is required for the development of IL-9-secreting T cells and allergic inflammation. 2010. Nat. Immunol. 11(6):527-534. * Contributed equally.
Contact
|
|
ritobrata.goswami@iitkgp.ac.in
|
phone |
+91 3222 260518
|
address |
School of Bio Science
Sir JC Bose Laboratory Complex IIT Kharagpur Kharagpur 721302 West Bengal |
