We aim to use state-of-the-art facilities to understand basic functional architecture of living systems with the aim to apply that knowledge to address disease mechanisms.
One aspect of deciphering diseases is to understand how macromolecules behave in normal and diseased states; biophysical methods such as X-ray crystallography, NMR spectroscopy, surface plasmon resonance (SPR) spectroscopy, analytical ultra-centrifugation (AUC) and isothermal titration calorimetry (ITC) will be used to study the molecular and structural basis of macromolecular functions.
To gain insight into infection biology, we study mechanism of assembly of viral replication machinery inside host cells using genetics, proteomics and molecular biology techniques. How our adaptive immune system is affected by nutrients like vitamin is another field of our study that is pursued in our department. Using the powerful model system (Drosophila) we aim to gain mechanistic insight into brain function during memory formation and in relation to injury, ageing and neurodegenerative disorders; we employ classical and molecular genetics, microscopy and genomic techniques like DamID & next-generation sequencing (NGS) to understand epigenetic link of memory and brain diseases.
In sum, our key areas of interest are - regulation of transcription factors, DNA repair mechanisms, protein folding and mis-folding, intrinsically disordered proteins, enzyme catalysis and protein engineering, assembly of viral macromolecular complexes, host-pathogen interactions, effect of nutrients in immune system, neuro-epigenetic basis of memory & brain disorders.
One aspect of deciphering diseases is to understand how macromolecules behave in normal and diseased states; biophysical methods such as X-ray crystallography, NMR spectroscopy, surface plasmon resonance (SPR) spectroscopy, analytical ultra-centrifugation (AUC) and isothermal titration calorimetry (ITC) will be used to study the molecular and structural basis of macromolecular functions.
To gain insight into infection biology, we study mechanism of assembly of viral replication machinery inside host cells using genetics, proteomics and molecular biology techniques. How our adaptive immune system is affected by nutrients like vitamin is another field of our study that is pursued in our department. Using the powerful model system (Drosophila) we aim to gain mechanistic insight into brain function during memory formation and in relation to injury, ageing and neurodegenerative disorders; we employ classical and molecular genetics, microscopy and genomic techniques like DamID & next-generation sequencing (NGS) to understand epigenetic link of memory and brain diseases.
In sum, our key areas of interest are - regulation of transcription factors, DNA repair mechanisms, protein folding and mis-folding, intrinsically disordered proteins, enzyme catalysis and protein engineering, assembly of viral macromolecular complexes, host-pathogen interactions, effect of nutrients in immune system, neuro-epigenetic basis of memory & brain disorders.
PHONE
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Office: +91-322-284550
Head: +91-322-284574 |
ADDRESS
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School of Bioscience,
1st and 2nd floor, Life Science Building Diamond Jubilee Complex Indian Institute of Technology Kharagpur West Bengal, India. PIN: 721302 |
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