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Dibyendu Samanta
Laboratory of Cell Adhesion & Host-Microbe (bacteria) interaction 1. Mechanism of nectin and cadherin-mediated cell-cell adhesion 2. Molecular and structural bases of T cell costimulation 3. Deciphering the mechanism of entry of bacterial pathogen into host cell 4. Protein engineering |
Contact
Email: dibyendu.samanta@iitkgp.ac.in Tel: +91-3222-260295 |
Dr. Dibyendu Samanta's laboratory focuses on structure-function relationship of membrane proteins, particularly membrane-bound immunoglobulin super-family (IgSF) members. These IgSFs play vital roles in a number of cellular and physiological processes including cell-cell adhesion, immune modulation, host-pathogen interaction etc. Dr. Samanta's lab aims to understand the detail molecular mechanisms of interactions among IgSF members, and finally modulate these interactions utilizing structure-guided protein engineering approach. Understanding and engineering of these IgSF members will provide further insights for the development of novel protein-based therapeutics. Currently, Dr. Samant's lab working on the following areas:
1. Understanding the mechanism of nectin and cadherin-mediated cell-cell adhesion
2. Understanding molecular and structural bases of T cell costimulation
3. Deciphering the mechanism of entry of Mycobacterium tuberculosis into pneumocytes
1. Understanding the mechanism of nectin and cadherin-mediated cell-cell adhesion
2. Understanding molecular and structural bases of T cell costimulation
3. Deciphering the mechanism of entry of Mycobacterium tuberculosis into pneumocytes
Professional Experiences:
Assistant Professor (2015- present): School of Bioscience, Indian Institute of Technology Kharagpur, India
Associate Faculty (2013-2015): Department of Biochemistry, Albert Einstein College of Medicine, New York, USA
Post-Doctoral (2009-2013): Dept. of Microbiology & Immunology, Albert Einstein College of Medicine, New York, USA
Current Funding:
Completed Funding:
Lab Members:
1. Kheerthana Duraivelan
2. Aditya J. Basak
3. Bidisha Acharya
4. Shruti Chatterjee
5. Sagarika Dash
Selected Publications:
11. Duraivelan K and Samanta D*, Tracing the evolution of nectin and nectin-like cell adhesion molecules, Scientific Reports, 2020, 10(1):9434
10. Ng S. L., Leno-duran E. , Samanta D. , Almo S. C., Strominger J. L. Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells, Proc Natl Acad Sci USA, 2019, 116(7): 2634-2639
9. Duraivelan K., Basak A. J., Ghosh A. , Samanta D*. Molecular and structural bases of interaction between extracellular domains of nectin-2 and N-cadherin, Proteins, 2018, 86:1157-1164
8. Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC. Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2, Mol Immunol. 2017, 81:151-159
7. Samanta D*, Almo SC. Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity, Cell Mol Life Sci, 2015, 72(4):645-58.
6. Samanta D, Ramagopal UA, Rubinstein R, Vladimir V, Nathenson SG, Almo SC. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion, Proc Natl Acad Sci USA, 2012, 109(37):14836-40. (Highlighted in PSI-Nature Structural Biology Knowledgebase, March 2013)
5. Samanta D§ , Mukherjee G§ , Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC. Structural and Functional Characterization of a Single-chain Peptide-MHC Molecule that Modulates Both Naive and Activated CD8+ T Cells, Proc Natl Acad Sci USA, 2011, 108(33): 13682-87.
4. Samanta D*, Das A, Das D, Bhattacharya B, Basu A, Ghosh G, DasGupta C*. Ribosome Assisted Protein Folding: Some of its Biological Implications, Protein Folding, Nova Science Publisher, New York (An invited book chapter), 2010, 377-400.
3. Samanta D*, Das A, Bhattacharya A, Basu A, Das D, DasGupta C*. Mechanism of ribosome assisted protein folding: a new insight into rRNA functions, Biochem Biophys Res Commun, 2009, 384(2):137- 40.
2. Samanta D, Mukhopadhyay D, Chowdhury S, Ghosh J, Pal S, Basu A, Bhattacharya A, Das A, Das D, DasGupta C. Protein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactions, J Bacteriol, 2008, 190(9):3344-52.
1. Basu A§ , Samanta D§ , Bhattacharya A, Das A, Das D, Dasgupta C. Protein folding following synthesis in vitro and in vivo: association of newly synthesized protein with 50S subunit of E. coli ribosome, Biochem Biophys Res Commun, 2008, 366(2):592-97.
[ § Equally Contributed *Corresponding Author]
Assistant Professor (2015- present): School of Bioscience, Indian Institute of Technology Kharagpur, India
Associate Faculty (2013-2015): Department of Biochemistry, Albert Einstein College of Medicine, New York, USA
Post-Doctoral (2009-2013): Dept. of Microbiology & Immunology, Albert Einstein College of Medicine, New York, USA
Current Funding:
- Project Title : Molecular and Structural Studies of the Role of Host Adhesion Molecules in Facilitating LpqH (19 kDa Surface Antigen) Mediated Entry of Mycobacterium Tuberculosis into Pneumocytes
Principal Investigator : Dibyendu Samanta
Sponsor : MHRD-STARS (2020 to 2023) - Project Title : BTNL2, a Novel T Cell Coinhibitory Molecule, as a Therapeutic Target in Ulcerative Colitis
Co-Principal Investigator : Dibyendu Samanta
Sponsor : DBT, NEW DELHI (2019 to 2022)
Completed Funding:
- Project Title : Structure-function relationship and engineering of immunoglobulin super-family (IgSF) proteins: from mechanisms to therapeutics
Principal Investigator : Dibyendu Samanta
Sponsor : DST-SERB (March 2017 to February 2020) - Project Title : Identification of novel and therapeutically relevant molecular interactions involving immunoglobulin superfamily member
Principal Investigator : Dibyendu Samanta
Sponsor : ISIRD, IIT Kharagpur (Dec 2015 to Dec 2018)
Lab Members:
1. Kheerthana Duraivelan
2. Aditya J. Basak
3. Bidisha Acharya
4. Shruti Chatterjee
5. Sagarika Dash
Selected Publications:
11. Duraivelan K and Samanta D*, Tracing the evolution of nectin and nectin-like cell adhesion molecules, Scientific Reports, 2020, 10(1):9434
10. Ng S. L., Leno-duran E. , Samanta D. , Almo S. C., Strominger J. L. Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells, Proc Natl Acad Sci USA, 2019, 116(7): 2634-2639
9. Duraivelan K., Basak A. J., Ghosh A. , Samanta D*. Molecular and structural bases of interaction between extracellular domains of nectin-2 and N-cadherin, Proteins, 2018, 86:1157-1164
8. Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC. Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2, Mol Immunol. 2017, 81:151-159
7. Samanta D*, Almo SC. Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity, Cell Mol Life Sci, 2015, 72(4):645-58.
6. Samanta D, Ramagopal UA, Rubinstein R, Vladimir V, Nathenson SG, Almo SC. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion, Proc Natl Acad Sci USA, 2012, 109(37):14836-40. (Highlighted in PSI-Nature Structural Biology Knowledgebase, March 2013)
5. Samanta D§ , Mukherjee G§ , Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC. Structural and Functional Characterization of a Single-chain Peptide-MHC Molecule that Modulates Both Naive and Activated CD8+ T Cells, Proc Natl Acad Sci USA, 2011, 108(33): 13682-87.
4. Samanta D*, Das A, Das D, Bhattacharya B, Basu A, Ghosh G, DasGupta C*. Ribosome Assisted Protein Folding: Some of its Biological Implications, Protein Folding, Nova Science Publisher, New York (An invited book chapter), 2010, 377-400.
3. Samanta D*, Das A, Bhattacharya A, Basu A, Das D, DasGupta C*. Mechanism of ribosome assisted protein folding: a new insight into rRNA functions, Biochem Biophys Res Commun, 2009, 384(2):137- 40.
2. Samanta D, Mukhopadhyay D, Chowdhury S, Ghosh J, Pal S, Basu A, Bhattacharya A, Das A, Das D, DasGupta C. Protein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactions, J Bacteriol, 2008, 190(9):3344-52.
1. Basu A§ , Samanta D§ , Bhattacharya A, Das A, Das D, Dasgupta C. Protein folding following synthesis in vitro and in vivo: association of newly synthesized protein with 50S subunit of E. coli ribosome, Biochem Biophys Res Commun, 2008, 366(2):592-97.
[ § Equally Contributed *Corresponding Author]
